Abstract: Objective To investigate clinical outcomes and prognosis for patients undergoing multiple organ resection to treat locally advanced gastric cancer. Methods We retrospectively analyzed 93 patients with locally advanced gastric cancer who underwent multi-ple organ resection in our hospital between January 2002 and December 2009. Results Of the 93 patients，24 underwent distal pan-createctomy and splenectomy；17，splenectomy；10，transverse colectomy；10，left hepatectomy；7，cholecystectomy；5，diaphragmatic re-section；5，splenectomy；5，distal pancreatectomy plus transverse colectomy；5，double oopherectomy；4，left hepatectomy plus transverse colectomy；3，pancreatoduodenectomy；2，auxiliary adrenalectomy；and 1，distal pancreatectomy，splenectomy，left hepatectomy，diaphrag-matic resection and auxiliary adrenalectomy.The overall preoperative neoadjuvant chemotherapy rate was 25/93（26.88%），and tumor release grades were distributed as follows：grade 0，4 patients； grade 1，6 patients； grade 2，8 patients；grade 3，5 patients；and grade 4，2 patients.Postoperative morbidity and mortality rates were，respectively，29/93（31.18%）and 4/93（4.30%）.The 1- and 3-year overall survival rates were 50.11% and 26.12%， respectively. Conclusions Multiple organ resection is an effective treatment for locally ad-vanced gastric cancer and it improves survival rates. Preoperative neoadjuvant chemotherapy improves survival and resection rates.

Key words: Gastric neoplasms, Locally advanced gastric cancer, Combined multiple organ resection, Preoperative neoadjuvant chemotherapy, Comprehensive treatment